Structure-kinetic relationship studies of cannabinoid CB 2 receptor agonists reveal substituent-specific lipophilic effects on residence time-Reference-Cited by-同舟云学术

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Structure-kinetic relationship studies of cannabinoid CB 2 receptor agonists reveal substituent-specific lipophilic effects on residence time

Published:2018-06 Issue: Volume:152 Page:129-142
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Soethoudt Marjolein,Hoorens Mark W.H.,Doelman Ward,Martella Andrea,van der Stelt Mario,Heitman Laura H.

Funder

Netherlands Organisation for Scientific Research

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference63 articles.

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2. Drug-target residence time and its implications for lead optimization;Copeland;Nat. Rev. Drug Discov.,2006

3. Slow-onset inhibition of the fabl enoyl reductase from francisella tularensis: residence time and in vivo activity;Lu;Acs Chem. Biol.,2009

4. Correlating drug-target kinetics and in vivo pharmacodynamics: long residence time inhibitors of the FabI enoyl-ACP reductase;Daryaee;Chem. Sci.,2016

5. A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues;Gooljarsingh;Proc. Natl. Acad. Sci. U.S.A.,2006

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