Genetic polymorphisms of drug-metabolizing cytochrome P450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans-Reference-Cited by-同舟云学术

Genetic polymorphisms of drug-metabolizing cytochrome P450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans

Published:2018-07 Issue: Volume:153 Page:184-195
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Uno Yasuhiro,Uehara Shotaro,Yamazaki Hiroshi

Funder

Ministry of Education, Science, Sports and Culture of Japan

Strategic Research Foundation

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research

Medical Research and Development

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

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2. Utility of non-human primates in drug development: comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes;Uno;Biochem. Pharmacol.,2016

3. A null allele impairs function of CYP2C76 gene in cynomolgus monkeys: a possible genetic tool for generation of a better animal model in drug metabolism;Uno;Drug Metab. Dispos.,2009

4. CpG site degeneration triggered by the loss of functional constraint created a highly polymorphic macaque drug-metabolizing gene, CYP1A2;Uno;BMC Evol. Biol.,2011

5. CYP1B1 is polymorphic in cynomolgus and rhesus macaques;Uno;J. Ved. Med. Sci.,2011

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