Utility of non-human primates in drug development: Comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes

Author:

Uno Yasuhiro,Uehara Shotaro,Yamazaki Hiroshi

Funder

Construction of System for Spread of Primate Model Animals

Science Grants-in-Aid for Scientific Research

Ministry of Education, Science, Sports and Culture of Japan

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference68 articles.

1. The marmoset as an animal model for teratological research;Poswillo;Nature,1972

2. Macaque cytochromes P450: nomenclature, transcript, gene, genomic structure, and function;Uno;Drug Metab. Rev.,2011

3. A newly developed DNA microarray is useful to assess induction of cytochromes P450 in cynomolgus monkey;Ise;Drug Metab. Pharmacokinet.,2011

4. Species difference between cynomolgus monkeys and humans on cytochromes P450 2D and 3A-dependent drug oxidation activities in liver microsomes;Emoto;J. Health Sci.,2011

5. Comparison of P450 enzymes between cynomolgus monkeys and humans: P450 identities, protein contents, kinetic parameters, and potential for inhibitory profiles;Emoto;Curr. Drug Metab.,2013

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