Identification and validation of a novel dual small-molecule TLR2/8 antagonist-Reference-Cited by-同舟云学术

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Identification and validation of a novel dual small-molecule TLR2/8 antagonist

Published:2020-07 Issue: Volume:177 Page:113957
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Grabowski Maria,Bermudez Marcel,Rudolf Thomas,Šribar Dora,Varga Péter,Murgueitio Manuela S.,Wolber Gerhard,Rademann Jörg,Weindl Günther

Funder

Deutsche Forschungsgemeinschaft

German Academic Exchange Service

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference61 articles.

1. The history of Toll-like receptors - redefining innate immunity;O'Neill;Nat. Rev. Immunol.,2013

2. Pathogen recognition and innate immunity;Akira;Cell.,2006

3. Toll-like receptors and innate immunity;Kumar;Biochem. Biophys. Res. Commun.,2009

4. The Role of TLR2 in Infection and Immunity;Oliveira-Nascimento;Front. Immunol.,2012

5. Lipoproteins of Gram-Positive Bacteria: Key Players in the Immune Response and Virulence;Nguyen;Microbiol. Mol. Biol. Rev.,2016

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4. Further hit optimization of 6-(trifluoromethyl)pyrimidin-2-amine based TLR8 modulators: Synthesis, biological evaluation and structure–activity relationships;European Journal of Medicinal Chemistry;2021-12

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