Evaluating the abilities of diverse nitroaromatic prodrug metabolites to exit a model Gram negative vector for bacterial-directed enzyme-prodrug therapy-Reference-Cited by-同舟云学术

Evaluating the abilities of diverse nitroaromatic prodrug metabolites to exit a model Gram negative vector for bacterial-directed enzyme-prodrug therapy

Published:2018-12 Issue: Volume:158 Page:192-200
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Chan-Hyams Jasmine V.E.,Copp Janine N.,Smaill Jeff B.,Patterson Adam V.^ORCID,Ackerley David F.^ORCID

Funder

Royal Society of New Zealand Marsden Fund

Victoria University of Wellington

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference33 articles.

1. The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)-I. Purification and properties of a nitroreductase enzyme from Escherichia coli-A potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT);Anlezark;Biochem. Pharmacol.,1992

2. The bystander effect of nitroreductase/CB1954 enzyme/prodrug system is due to cell permeable metabolite;Bridgewater;Hum. Gene Ther.,1997

3. Virus-directed enzyme prodrug therapy with nitroimidazole reductase: a phase I and pharmacokinetic study of its prodrug, CB1954;Chung-Faye;Clin. Cancer Res.,2001

4. Toward a high-throughput screening platform for directed evolution of enzymes that activate genotoxic prodrugs;Copp;Protein Eng. Des. Sel.,2014

5. Engineering a multifunctional nitroreductase for improved activation of prodrugs and PET probes for cancer gene therapy;Copp;Cell Chem. Biol.,2017

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