Inhibition of human CYP2B6 by N,N′,N″-triethylenethiophosphoramide is irreversible and mechanism-based

Author:

Richter Tanja,Schwab Matthias,Eichelbaum Michel,Zanger Ulrich M.

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference35 articles.

1. Chemistry, pharmacology and pharmacokinetics of N,N′,N″-triethylenethiophosphoramide (thioTEPA);Maanen;Cancer Treat Rev,2000

2. Biotransformation of N,N′,N″-triethylenethiophosphoramide: oxidative desulfuration to yield N,N′,N″-triethylenephosphoramide associated with suicide inactivation of a phenobarbital-inducible hepatic P450 monooxygenase;Ng;Cancer Res,1990

3. N,N′,N″-triethylenethiophosphoramide (thioTEPA) oxygenation by constitutive hepatic P450 enzymes and modulation of drug metabolism and clearance in vivo by P450-inducing agents;Ng;Cancer Res,1991

4. Cytochrome P450 isozymes 3A4 and 2B6 are involved in the in vitro human metabolism of thiotpea to TEPA;Jacobson;Cancer Chemother Pharmacol,2002

5. Phase I/pharmacokinetic reevaluation of thioTEPA;O’Dwyer;Cancer Res,1991

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