Anabolism of amdoxovir: phosphorylation of dioxolane guanosine and its 5′-phosphates by mammalian phosphotransferases

Author:

Feng Joy Y.,Parker William B.,Krajewski Megan L.,Deville-Bonne Dominique,Veron Michel,Krishnan Preethi,Cheng Yung-Chi,Borroto-Esoda Katyna

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference47 articles.

1. Phosphorylation of nucleoside analog antiretrovirals: a review for clinicians;Stein;Pharmacol. Ther.,2001

2. Mechanism of action of 1-b-D-2,6-diaminopurine dioxolane, a prodrug of the human immnuodeficiency virus type 1 inhibitor 1-b-D-dioxolane guanosine;Furman;Antimicro. Agents Chemother.,2001

3. The disposition of DAPD and it active metabolite DXG in therapy naive and experienced HIV-infected subjects (Abstract 752);Wang,2001

4. Dioxolane guanosine, the active form of the prodrug diaminopurine dioxolane, is a potent inhibitor of drug-resistant HIV-1 isolates from patients failing standard nucleoside therapy;Mewshaw;J. AIDS,2002

5. Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89;Faletto;Antimicrob. Agents Chemother.,1997

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