Kinetic binding and activation profiles of endogenous tachykinins targeting the NK1 receptor

Author:

Nederpelt I.,Bleeker D.,Tuijt B.,IJzerman A.P.,Heitman L.H.

Funder

European Union’s Seventh Framework Programme

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference48 articles.

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2. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action;Vauquelin;Br. J. Pharmacol.,2010

3. Residence time of receptor-ligand complexes and its effect on biological function;Tummino;Biochemistry,2008

4. The role of binding kinetics in therapeutically useful drug action;Swinney;Curr. Opin. Drug Discov. Devel.,2009

5. Drug-target residence time-a case for G protein-coupled receptors;Guo;Med. Res. Rev.,2014

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