Drug-DNA adducts as biomarkers for metabolic activation of the nitro-aromatic nitrogen mustard prodrug PR-104A-Reference-Cited by-同舟云学术

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Drug-DNA adducts as biomarkers for metabolic activation of the nitro-aromatic nitrogen mustard prodrug PR-104A

Published:2018-08 Issue: Volume:154 Page:64-74
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Stornetta Alessia,Deng Kai-Cheng Kieren,Danielli Sara,Liyanage H.D. Sarath,Sturla Shana J.,Wilson William R.,Gu Yongchuan

Funder

Health Research Council of New Zealand

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Marsden Fund

Auckland Medical Research Foundation

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference37 articles.

1. DNA interstrand crosslink repair and cancer;Deans;Nat. Rev. Cancer,2011

2. Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A;Gu;Mol. Cancer Ther.,2009

3. DNA interstrand crosslink repair in mammalian cells: step by step;Muniandy;Crit. Rev. Biochem. Mol. Biol.,2010

4. The role of DNA repair in nitrogen mustard drug resistance;Panasci;Anticancer Drugs,2002

5. A phase I trial of PR-104, a nitrogen mustard prodrug activated by both hypoxia and aldo-keto reductase 1C3, in patients with solid tumors;Jameson;Cancer Chemother. Pharmacol.,2010

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1. DNA Adducts in Cancer Chemotherapy;Journal of Medicinal Chemistry;2024-03-29

2. Nitroaromatic Hypoxia-Activated Prodrugs for Cancer Therapy;Pharmaceuticals;2022-02-02

3. In Vivo Identification of Adducts from the New Hypoxia-Activated Prodrug CP-506 Using DNA Adductomics;Chemical Research in Toxicology;2022-01-20

4. Synthesis and evaluation of new dinitrobenzamide mustards in human prostate cancer;Bioorganic & Medicinal Chemistry Letters;2021-01

5. Hypoxia-selective radiosensitisation by SN38023, a bioreductive prodrug of DNA-dependent protein kinase inhibitor IC87361;Biochemical Pharmacology;2019-11

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