KN-93 inhibits IKr in mammalian cardiomyocytes

Author:

Hegyi Bence,Chen-Izu Ye,Jian Zhong,Shimkunas Rafael,Izu Leighton T.,Banyasz TamasORCID

Funder

Hungarian Scientific Research Fund

National Institute of Health

Publisher

Elsevier BV

Subject

Cardiology and Cardiovascular Medicine,Molecular Biology

Reference13 articles.

1. CaMKII inhibitors: from research tools to therapeutic agents;Pellicena;Front. Pharmacol.,2014

2. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early after depolarizations in rabbit heart;Anderson;J. Pharmacol. Exp. Ther.,1998

3. Calmodulin kinase signaling in heart: an intriguing candidate target for therapy of myocardial dysfunction and arrhythmias;Anderson;Pharmacol. Ther.,2005

4. Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice;Chelu;J. Clin. Invest.,2009

5. Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias;Swaminathan;Circ. Res.,2012

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