Synthesis, biological evaluation and X-ray crystallographic analysis of novel (E)-2-cyano-3-(het)arylacrylamides as potential anticancer agents-Reference-Cited by-同舟云学术

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Synthesis, biological evaluation and X-ray crystallographic analysis of novel (E)-2-cyano-3-(het)arylacrylamides as potential anticancer agents

Published:2021-11 Issue: Volume:1244 Page:130944
ISSN:0022-2860
Container-title:Journal of Molecular Structure
language:en
Short-container-title:Journal of Molecular Structure

Author:

Serrano-Sterling Camilo,Becerra Diana,Portilla Jaime,Rojas Hugo,Macías Mario,Castillo Juan-Carlos

Funder

Universidad de los Andes

Publisher

Elsevier BV

Subject

Inorganic Chemistry,Organic Chemistry,Spectroscopy,Analytical Chemistry

Reference62 articles.

1. Allenamide as a bioisostere of acrylamide in the design and synthesis of targeted covalent inhibitors;Chen;Med. Chem. Commun.,2018

2. Covalent inhibition in drug discovery;Ghosh;ChemMedChem,2019

3. The resurgence of covalent drugs;Singh;Nat. Rev. Drug Discov.,2011

4. Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies;Bauer;Drug Discov. Today,2015

5. Acrylamide functional group incorporation improves drug-like properties: an example with EGFR inhibitors;Wu;ACS Med. Chem. Lett.,2019

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1. Synthesis and photophysical properties of 3-aryl-2-cyanoacrylamides: Design of a turn-on fluorescent probe for cyanide ion detection;Journal of Molecular Structure;2025-02

2. Crystal structure, spectroscopy, DFT, and thermal studies of 3-cyano-2(1H)-pyridones as potential anticancer agents;RSC Advances;2024

3. Regioselective N-sulfonylation of 3-(methylthio)-1H-1,2,4-triazol-5-amine: Spectroscopic, thermal, crystal structure, and anticancer studies;Journal of Molecular Structure;2024-01

4. Synthesis and Biological Studies of Benzo[b]furan Derivatives: A Review from 2011 to 2022;Pharmaceuticals;2023-09-06

5. Cytotoxic Effect of New (E)‐2‐Cyano‐N‐(tetrahydrobenzo[b]thiophen‐2‐yl)acrylamide Derivatives: Down‐Regulation of RBL2 and STAT2 and Triggering of DNA Damage in Breast Carcinoma;ChemistrySelect;2023-09

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