The nitro-reduced metabolite of nimesulide: Crystal structure, spectroscopic characterization, ESI-QTOF mass spectrometric analysis and antibacterial evaluation

Author:

Nunes Julia H.B.,Nakahata Douglas H.,Lustri Wilton R.,Corbi Pedro P.,de Paiva Raphael E.F.ORCID

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

Elsevier BV

Subject

Inorganic Chemistry,Organic Chemistry,Spectroscopy,Analytical Chemistry

Reference27 articles.

1. Nimesulide;Valentovic,2007

2. Simultaneous determination of nimesulide and its four possible metabolites in human plasma by LC–MS/MS and its application in a study of pharmacokinetics;Sun;J. Chromatogr. B,2016

3. Mass spectrometric characterization and HPLC determination of the main urinary metabolites of nimesulide in man;Carini;J. Pharmaceut. Biomed. Anal.,1998

4. The biotransformation and pharmacokinetics of 14C-nimesulide in humans following a single dose oral administration;Macpherson;J. Drug Metabol. Toxicol.,2012

5. A nimesulide derivative with potential anti-inflammatory activity: synthesis, X-ray powder structure analysis and DFT study;Bhattacharya;J. Mol. Struct.,2010

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