Deficiency of MTH1 and/or OGG1 increases the accumulation of 8-oxoguanine in the brain of the AppNL-G-F/NL-G-F knock-in mouse model of Alzheimer’s disease, accompanied by accelerated microgliosis and reduced anxiety-like behavior-Reference-Cited by-同舟云学术

Deficiency of MTH1 and/or OGG1 increases the accumulation of 8-oxoguanine in the brain of the AppNL-G-F/NL-G-F knock-in mouse model of Alzheimer’s disease, accompanied by accelerated microgliosis and reduced anxiety-like behavior

Published:2021-11 Issue: Volume: Page:
ISSN:0168-0102
Container-title:Neuroscience Research
language:en
Short-container-title:Neuroscience Research

Author:

Mizuno Yuri,Abolhassani Nona^ORCID,Mazzei Guianfranco^ORCID,Saito Takashi^ORCID,Saido Takaomi C.,Yamasaki Ryo,Kira Jun-ichi,Nakabeppu Yusaku^ORCID

Funder

Japan Society for the Promotion of Science

Kyushu University

Publisher

Elsevier BV

Subject

General Medicine,General Neuroscience

Reference52 articles.

1. Nucleic acid oxidation: an early feature of Alzheimer’s disease;Bradley-Whitman;J. Neurochem.,2014

2. Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation;Castillo;Sci. Rep.,2017

3. Expression of hMTH1 in the hippocampi of control and Alzheimer’s disease;Furuta;Neuroreport,2001

4. Increased nuclear DNA oxidation in the brain in alzheimer’s disease;Gabbita;J. Neurochem.,1998

5. 8-Oxoguanine accumulation in aged female brain impairs neurogenesis in the dentate gyrus and major island of Calleja, causing sexually dimorphic phenotypes;Haruyama;Prog. Neurobiol.,2019

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Oxidative stress–mediated neuroinflammation in Alzheimer’s disease;Naunyn-Schmiedeberg's Archives of Pharmacology;2024-06-04

2. Long-term suboptimal dietary trace element supply does not affect trace element homeostasis in murine cerebellum;Metallomics;2024-01-31

3. Targeting the nucleic acid oxidative damage repair enzyme MTH1: a promising therapeutic option;Frontiers in Cell and Developmental Biology;2024-01-31

4. Applications of App and MAPT knock-in mice to understanding disease mechanisms;Alzheimer' s Disease Research Guide;2024

5. Repeated multi-domain cognitive training prevents cognitive decline, anxiety and amyloid pathology found in a mouse model of Alzheimer disease;Communications Biology;2023-11-10