Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract

Author:

Kon Risako,Ikarashi Nobutomo,Nagoya Chika,Takayama Tomoko,Kusunoki Yoshiki,Ishii Makoto,Ueda Harumi,Ochiai Wataru,Machida Yoshiaki,Sugita Kazuyuki,Sugiyama KiyoshiORCID

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology

Reference39 articles.

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2. Laxatives and the production of autacoids by rat colon;Capasso;J. Pharm. Pharmacol.,1986

3. Metabolism and pharmacokinetics of anthranoids;de Witte;Pharmacology,1993

4. The metabolism of anthranoid laxatives;de Witte;Hepatogastroenterology,1990

5. Involvement of PGE2 and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages;Diaz-Munoz;Biochem. J.,2012

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