Pharmacokinetics and metabolism study of isoboldine, a major bioactive component from Radix Linderae in male rats by UPLC–MS/MS

Author:

Li Yu,Zeng Rong-jie,Chen Jian-zhong,Wu Yan-bin,Chou Gui-xin,Gao Yu,Shao Jing-wei,Cai Hua-zhu,Jia Lee

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology

Reference11 articles.

1. Pharmacokinetics and bioavailibility of norisoboldine and its metabolite in rats;Chen;Chin. J. Mod. Appl. Pharm.,2012

2. Characterization of new metabolites from in vivo biotransformation of norisoboldine by liquid chromatography/mass spectrometry and NMR spectroscopy;Chen;J. Pharm. Biomed. Anal.,2010

3. Simultaneous determination of norisoboldine and its major metabolite in rat plasma by ultra-performance liquid chromatography–mass spectrometry and its application in a pharmacokinetic study;Chen;Biomed. Chromatogr.,2011

4. Alkaloids of Linderae Radix suppressed the lipopolysaccharide-induced expression of cytokines in cultured macrophage RAW 264.7 cells;Chou;Tang,2014

5. Isoquinoline alkaloids from Lindera aggregate;Chou;Chin. J. Nat. Med.,2005

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