Pharmacokinetic profiles of hydroxysafflor yellow A following intravenous administration of its pure preparations in healthy Chinese volunteers

Author:

Li Chang-Yin,Yin Jun-Gang,Zhang Jun,Wang Xiao-Xiao,Xu Mei-Juan,Liu Fang,Zou Jian-Dong,Ju Wen-Zheng

Funder

Leading Talents of Scientific Research in TCM of Jiangsu Province

National Science and Technology Major Project

Jiangsu Higher Education Institutions

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology

Reference22 articles.

1. Hydroxysafflor yellow A protects against cerebral ischemia-reperfusion injury by anti-apoptotic effect through PI3K/Akt/GSK3beta pathway in rat;Chen;Neurochemical Research,2013

2. European Agency for the Evaluation of Medicinal Products, 2005. Internationnal conference on harmonisation world health organization. Guideline for good clinical practice [emeaweb site]. Ich topic e6 (http://www.emea.eu.int)

3. Exploratory assessment of dose proportionality: review of current approaches and proposal for a practical criterion;Hummel;Pharmaceutical Statistics,2009

4. Hydroxysafflor yellow A induces apoptosis in activated hepatic stellate cells through ERK1/2 pathway in vitro;Li;European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences,2012

5. Clinical pharmacokinetics of tonapofylline: evaluation of dose proportionality, oral bioavailability, and gender and food effects in healthy human subjects;Li;Journal of Clinical Pharmacology,2011

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