An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome-Reference-Cited by-同舟云学术

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An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome

Published:2017-08 Issue: Volume:64 Page:101-107
ISSN:0143-4179
Container-title:Neuropeptides
language:en
Short-container-title:Neuropeptides

Author:

Hay Elizabeth Anne,Khalaf Abdulla Razak,Marini Pietro,Brown Andrew,Heath Karyn,Sheppard Darrin,MacKenzie Alasdair

Funder

Wellcome Trust

Medical Research Scotland

GW Pharmaceuticals

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Endocrine and Autonomic Systems,Neurology,Endocrinology,General Medicine

Reference20 articles.

1. Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes;Chu;BMC Biotechnol.,2016

2. Differential activity by polymorphic variants of a remote enhancer that supports galanin expression in the hypothalamus and amygdala: implications for obesity, depression and alcoholism;Davidson;Neuropsychopharmacology,2011

3. Galanin receptors as a potential target for neurological disease;Freimann;Expert Opin. Ther. Targets,2015

4. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells;Fu;Nat. Biotechnol.,2013

5. Mouse Genome Editing Using the CRISPR/Cas System;Harms;Curr. Protoc. Hum. Genet.,2014

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