γ-Secretase Inhibitors: From Chemical Probes to Drug Development

Author:

Hur J.-Y.,Gertsik N.,Johnson D.S.,Li Y.-M.

Publisher

Elsevier

Reference103 articles.

1. Activation and intrinsic γ-secretase activity of presenilin 1;Ahn;Proc Natl Acad Sci USA,2010

2. Alzforum: Semagacestat failure analysis: should γ-secretase remain a target?, 2015. Available from: http://wwwalzforumorg/news/research-news/semagacestat-failure-analysis-should-g-secretase-remain-target

3. In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand;Beher;Biochemistry,2003

4. The novel gamma secretase inhibitor N-[cis-4- [(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of Notch-related pathology in the Tg2576 mouse;Best;J Pharmacol Exp Ther,2007

5. Biogen: Biogen Idec presents positive interim results from phase 1B study of investigational Alzheimer’s disease treatment aducanumab (BIIB037) at 2015 AD/PD™ Conference, 2015. Available from: http://mediabiogencom/press-release/corporate/biogen-idec-presents-positive-interim-results-phase-1b-study-investigational

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