Generation of Leads for γ-Secretase Modulation-Reference-Cited by-同舟云学术

Generation of Leads for γ-Secretase Modulation

Published:2020-07-27 Issue:15 Volume:63 Page:8216-8230
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mandal Mihirbaran¹^ORCID,Buevich Alexei²^ORCID,Caldwell John P.¹,Hyde Lynn³,Huang Xianhai¹^ORCID,Liu Xiaoxiang¹,McKittrick Brian¹,Mazzola Robert D.¹,Pissarnitski Dmitri¹,Palani Anandan¹,Zhang Lili³,Parker Eric³,Xiao Li⁴,Rindgen Diane⁵,Zhu Zhaoning¹

Affiliation:

1. Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

2. Department of NMR Structure Elucidation, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

3. Department of Neuroscience, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

4. Department of Modeling and Informatics, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

5. Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00446

Reference55 articles.

1. aAlzheimer’s Association. Alzheimer’s Disease Facts and Figures, 2017. http://www.alz.org/documentscustom/2017-facts-and-figures.pdf (accessed July, 2017).

2. bAlzheimer’s Disease International. World Alzheimer Report, 2016. https://www.alz.co.uk/research/WorldAlzheimerReport2016.pdf (accessed July 7, 2017).

3. aAlzheimer’s Association. FDA-approved drugs, 2017. http://www.alz.org/research/science/alzheimersdiseasetreatments.asp (accessed July, 2017).

4. Current Treatment for Alzheimer Disease and Future Prospects

5. Mechanisms Behind the Neuroprotective Actions of Cholinesterase Inhibitors in Alzheimer Disease

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