Hierarchical endpoints in critical care: A post-hoc exploratory analysis of the standard versus accelerated initiation of renal-replacement therapy in acute kidney injury and the intensity of continuous renal-replacement therapy in critically ill patients trials

Author:

Zampieri Fernando G.,Serpa-Neto Ary,Wald Ron,Bellomo Rinaldo,Bagshaw Sean M.

Funder

Canada Research Chairs

National Health and Medical Research Council

Canadian Institutes of Health Research

Health Research Council of New Zealand

Publisher

Elsevier BV

Reference13 articles.

1. Reappraisal of ventilator-free days in critical care research;Yehya;Am J Respir Crit Care Med,2019

2. The win ratio: a new approach to the analysis of composite endpoints in clinical trials based on clinical priorities;Pocock;Eur Heart J,2012

3. The win ratio approach for composite endpoints: practical guidance based on previous experience;Redfors;Eur Heart J,2020

4. Timing of initiation of renal-replacement therapy in acute kidney injury;STARRT-AKI Investigators; Canadian Critical Care Trials Group; Australian and New Zealand Intensive Care Society Clinical Trials Group; United Kingdom Critical Care Research Group; Canadian Nephrology Trials Network; Irish Critical Care Trials Group;N Engl J Med.,2020

5. Intensity of continuous renal-replacement therapy in critically ill patients;RENAL Replacement Therapy Study Investigators;N Engl J Med,2009

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