Combination of 4-hydroperoxy cyclophosphamide and methotrexate inhibits IL-6/sIL-6R-induced RANKL expression in fibroblast-like synoviocytes via suppression of the JAK2/STAT3 and p38MAPK signaling pathway-Reference-Cited by-同舟云学术

Combination of 4-hydroperoxy cyclophosphamide and methotrexate inhibits IL-6/sIL-6R-induced RANKL expression in fibroblast-like synoviocytes via suppression of the JAK2/STAT3 and p38MAPK signaling pathway

Published:2018-08 Issue: Volume:61 Page:45-53
ISSN:1567-5769
Container-title:International Immunopharmacology
language:en
Short-container-title:International Immunopharmacology

Author:

Niu Hong-Qing,Zhao Wen-Peng,Zhao Xiang-Cong,Luo Jing,Qin Kai-Li,Chen Kai-Lin,Li Xiao-Feng

Funder

National Natural Science Foundation of China

Scientific Research Foundation of Health and Family Planning Commission of Shanxi Province, China

Education Department of Shanxi Province

Publisher

Elsevier BV

Subject

Pharmacology,Immunology,Immunology and Allergy

Reference28 articles.

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3. TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis;Pettit;Am. J. Pathol.,2001

4. Evidence for treating rheumatoid arthritis to target: results of a systematic literature search update;Goswami;Ann. Rheum. Dis.,2016

5. Combination with methotrexate and cyclophosphamide attenuated maturation of dendritic cells: inducing Treg skewing and Th17 suppression in vivo;Yu;Clin. Dev. Immunol.,2013

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1. Application and pharmacological mechanism of methotrexate in rheumatoid arthritis;Biomedicine & Pharmacotherapy;2022-06

2. Triptolide Inhibits Expression of Inflammatory Cytokines and Proliferation of Fibroblast-like Synoviocytes Induced by IL-6/sIL-6R-Mediated JAK2/STAT3 Signaling Pathway;Current Medical Science;2021-02

3. miR-21a in exosomes from Lewis lung carcinoma cells accelerates tumor growth through targeting PDCD4 to enhance expansion of myeloid-derived suppressor cells;Oncogene;2020-08-27