Akt, mTOR and NF-κB pathway activation in Treponema pallidum stimulates M1 macrophages

Author:

Lin Li-Rong,Gao Zheng-Xiang,Lin Yong,Zhu Xiao-Zhen,Liu Wei,Liu Dan,Gao Kun,Tong Man-Li,Zhang Hui-Lin,Liu Li-Li,Xiao Yao,Niu Jian-Jun,Liu Fan,Yang Tian-CiORCID

Funder

National Natural Science Foundation

Key Projects for Province Science and Technology Program of Fujian

National Science Foundation for Distinguished Young Scholars of Fujian

Major Special Projects for Serious Illness of Xiamen

Natural Science Foundation of Fujian Province

Publisher

Elsevier BV

Subject

Pharmacology,Immunology,Immunology and Allergy

Reference21 articles.

1. Robust pro-inflammatory immune response is associated with serological cure in patients with syphilis: an observational study;Pastuszczak;Sex. Transm. Infect.,2017

2. Human macrophage polarization enhances opsonophagocytosis and inflammatory response of the stealth pathogen, Treponema pallidum;Hawley;Front. Immunol.,2015

3. Macrophage-mediated killing of opsonized Treponema pallidum;Baker-Zander Sharon;J. Infect. Dis.,1992

4. Primary and secondary syphilis lesions contain mRNA for Th1 cytokines;van Voorhis;J. Infect. Dis.,1996

5. Production of tumor necrosis factor alpha by Treponema pallidum, Borrelia burgdorferi s.l., and Leptospira interrogans in isolated rat Kupffer cells;Bako;FEMS Immunol. Med. Microbiol.,2004

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