Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations-Reference-Cited by-同舟云学术

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations

Published:2008-12 Issue:3 Volume:85 Page:201-206
ISSN:0014-4800
Container-title:Experimental and Molecular Pathology
language:en
Short-container-title:Experimental and Molecular Pathology

Author:

Segditsas Stefania,Sieber Oliver M.,Rowan Andrew,Setien Fernando,Neale Kay,Phillips Robin K.S.,Ward Robyn,Esteller Manel,Tomlinson Ian P.M.

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Molecular Biology,Pathology and Forensic Medicine

Reference28 articles.

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2. APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q;Arnold;Cancer Biol. Ther.,2004

3. Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia;Bai;Int. J. Cancer,2004

4. Alterations in DNA methylation: a fundamental aspect of neoplasia;Baylin;Adv. Cancer Res.,1998

5. Refining the relation between ‛first hits’ and ‛second hits’ at the APC locus: the ‛loose fit’ model and evidence for differences in somatic mutation spectra among patients;Crabtree;Oncogene,2003

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