Epigenetics and its therapeutic potential in colorectal cancer-Reference-Cited by-同舟云学术

Epigenetics and its therapeutic potential in colorectal cancer

Published:2022-06 Issue:11 Volume:14 Page:683-697
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Oryani Mahsa Akbari¹^ORCID,Tavasoli Afsaneh²^ORCID,Ghalavand Mohammad Amin³^ORCID,Ashtiani Rahele Zokaei⁴^ORCID,Rezaee Alisam⁵^ORCID,Mahmoudi Rasadokht⁶,Golvari Hossein⁷,Owrangi Soroor⁸^ORCID,Soleymani-Goloujeh Mehdi⁹^ORCID

Affiliation:

1. Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2. Department of Biotechnology, Faculty of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran

3. Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

4. Faculty of Medicine, Islamic Azad University Shahrood Branch, Semnan, Iran

5. Faculty of Medical Sciences & Technologies, Science & Research Branch, Islamic Azad University, Tehran, Iran

6. Faculty of Pharmacy, Comenius University, Bratislava, Slovakia

7. School of Nursing & Paramedical Sciences, Mazandaran University of Medical Sciences, Sari, Iran

8. Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran

9. Department of Stem Cells & Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology & Technology, ACECR, Tehran, Iran

Abstract

It is estimated that colorectal cancer (CRC) is the leading cause of cancer-related death around the globe. ‘Epigenetics’ refers to changes in the chromosome rather than the DNA sequence, which may be transmitted down to daughter cells. Epigenetics is an essential part of controlling the development and variation of a single cell. ncRNAs have a role in epigenetic regulation in CRC, which will be discussed in this review in the context of DNA methylation and histone modifications. A greater survival rate for CRC patients might be achieved by addressing epigenetic mediators, as the authors show. In this review, they aim to thoroughly examine the role of epigenetics in the prognosis, diagnosis and treatment of CRC.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2022-0067

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