Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling

Author:

Zhang Zhenzhou,Tang Jianqiong,Song Jiawei,Xie Mengshi,Liu Ying,Dong Zhaojie,Liu Xiaoyan,Li Xueting,Zhang Miwen,Chen Yihang,Shi Hongyu,Zhong JiuchangORCID

Publisher

Elsevier BV

Subject

Physiology (medical),Biochemistry

Reference36 articles.

1. Hypertension and heart failure: prevention, targets, and treatment. Heart fail;Di Palo;Clinic,2020

2. Heart failure with preserved ejection fraction;Redfield;N. Engl. J. Med.,2016

3. Cardiac remodeling: endothelial cells have more to say than just NO;Segers;Front. Physiol.,2018

4. NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis;Dodson;Redox Biol.,2019

5. Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell;Bai;Free Radic. Biol. Med.,2020

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