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A small molecule activator of SIRT3 promotes deacetylation and activation of manganese superoxide dismutase

  • Published:2017-11 Issue: Volume:112 Page:287-297
  • ISSN:0891-5849
  • Container-title:Free Radical Biology and Medicine
  • language:en
  • Short-container-title:Free Radical Biology and Medicine

Author:

Lu Jiaqi,Zhang Hua,Chen Xian,Zou Yong,Li Jiasong,Wang Li,Wu Minhao,Zang Jianye,Yu Yang,Zhuang Wei,Xia Qing,Wang Jiangyun

Funder

National Natural Science Foundation of China

Major State Basic Research Program of China

CAS

National Science and Technology Major Projects for "Major New Drugs Innovation and Development

NSFC

Strategic Priority Research Program

Publisher

Elsevier BV

Subject

Physiology (medical),Biochemistry

Reference46 articles.

1. Metabolic regulation of gene expression through histone acylations;Sabari;Nat. Rev. Mol. Cell Biol.,2016

2. Sirtuins: guardians of mammalian healthspan;Giblin;Trends Genet.,2014

3. Using mitochondrial sirtuins as drug targets: disease implications and available compounds;Gertz;Cell Mol. Life Sci.,2016

4. Acetylation site specificities of lysine deacetylase inhibitors in human cells;Scholz;Nat. Biotechnol.,2015

5. Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS;Chen;EMBO Rep.,2011

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