Using mitochondrial sirtuins as drug targets: disease implications and available compounds-Reference-Cited by-同舟云学术

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Using mitochondrial sirtuins as drug targets: disease implications and available compounds

Published:2016-03-23 Issue:15 Volume:73 Page:2871-2896
ISSN:1420-682X
Container-title:Cellular and Molecular Life Sciences
language:en
Short-container-title:Cell. Mol. Life Sci.

Author:

Gertz Melanie,Steegborn Clemens

Funder

Deutsche Forschungsgemeinschaft (DE)

Deutsche Forschungsgemeinschaft

Oberfrankenstiftung

Alzheimer Forschungsinitiative (DE)

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Cellular and Molecular Neuroscience,Pharmacology,Molecular Biology,Molecular Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00018-016-2180-7.pdf

Reference239 articles.

1. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325:834–840

2. Norvell A, McMahon SB (2010) Cell biology. Rise of the rival. Science 327:964–965

3. Rauh D, Fischer F, Gertz M, Lakshminarasimhan M, Bergbrede T, Aladini F, Kambach C, Becker CFW, Zerweck J, Schutkowski M, Steegborn C (2013) An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms. Nat Commun 4:2327

4. Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW (2013) Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci USA 110:6601–6606

5. Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ (2013) Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation. J Biol Chem 288:26209–26219

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