Modelling chemical kinetics of a complex reaction network of active pharmaceutical ingredient (API) synthesis with process optimization for benzazepine heterocyclic compound

Author:

Grom M.,Stavber G.,Drnovšek P.,Likozar B.

Publisher

Elsevier BV

Subject

Industrial and Manufacturing Engineering,General Chemical Engineering,Environmental Chemistry,General Chemistry

Reference32 articles.

1. U.K. Singh, C.J. Orella, Reaction kinetics and characterization, in: D.J. am Ende (Ed.), Chemical Engineering in the Pharmaceutical Industry: R&D to manufacturing, Wiley, Hoboken, 2011, pp. 79–99.

2. Predicting pharmaceutical degradation by UV (LP)/H2O2 processes: a kinetic model;Wols;Chem. Eng. J.,2014

3. Comprehensive determination of the solid state stability of bethanechol chloride active pharmaceutical ingredient using combined analytical tools;Rotival;CrystEngComm,2013

4. Optimising reaction performance in the pharmaceutical industry by monitoring with NMR;Bernstein;Magn. Reson. Chem.,2007

5. Use of modeling and process analytical technologies in the design of a catalytic amination reaction: understanding oxygen sensitivity at the lab and manufacturing scales;Merritt;Org. Process Res. Dev.,2014

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