MRI-based brain atrophy rates in ADNI phase 2: acceleration and enrichment considerations for clinical trials

Author:

Hua Xue,Ching Christopher R.K.,Mezher AdamORCID,Gutman Boris A.,Hibar Derrek P.,Bhatt Priya,Leow Alex D.,Jack Clifford R.,Bernstein Matt A.,Weiner Michael W.,Thompson Paul M.

Funder

Alzheimer’s Disease Neuroimaging Initiative

National Institutes of Health

DOD

ADNI

National Institute on Aging

National Institute of Biomedical Imaging and Bioengineering

University of California

ENIGMA Center

NIH

Publisher

Elsevier BV

Subject

Geriatrics and Gerontology,Developmental Biology,Neurology (clinical),Aging,General Neuroscience

Reference73 articles.

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3. Carmichael OT, Thompson PM, Dutton RA, Lu A, Lee SE, Lee JY, Kuller LH, Lopez OL, Aizenstein HJ, Meltzer CC, Liu Y, Toga AW, Becker, JT. Mapping ventricular changes related to dementia and mild cognitive impairment in a large community-based cohort. IEEE International Symposium on Biomedical Imaging. 2006;315–318.

4. Twelve-month metabolic declines in probable Alzheimer's disease and amnestic mild cognitive impairment assessed using an empirically pre-defined statistical region-of-interest: findings from the Alzheimer's Disease Neuroimaging Initiative;Chen;Neuroimage,2010

5. An automated algorithm for the computation of brain volume change from sequential MRIs using an iterative principal component analysis and its evaluation for the assessment of whole-brain atrophy rates in patients with probable Alzheimer's disease;Chen;Neuroimage,2004

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