All-Optical Electrophysiology Refines Populations of In Silico Human iPSC-CMs for Drug Evaluation-Reference-Cited by-同舟云学术

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All-Optical Electrophysiology Refines Populations of In Silico Human iPSC-CMs for Drug Evaluation

Published:2020-05 Issue:10 Volume:118 Page:2596-2611
ISSN:0006-3495
Container-title:Biophysical Journal
language:en
Short-container-title:Biophysical Journal

Author:

Paci Michelangelo^ORCID,Passini Elisa^ORCID,Klimas Aleksandra,Severi Stefano^ORCID,Hyttinen Jari,Rodriguez Blanca,Entcheva Emilia

Funder

Academy of Finland

NC3Rs Infrastructure for Impact Award

Wellcome Trust

EPSRC Impact Acceleration Awards

CompBioMed

Oxford BHF Centre of Research Excellence

TransQST

European Union’s Horizon 2020

National Institutes of Health

National Science Foundation

Publisher

Elsevier BV

Subject

Biophysics

Reference65 articles.

1. Comprehensive in vitro proarrhythmia assay (CiPA) update from a cardiac safety research consortium/health and environmental sciences institute/FDA meeting;Strauss;Ther. Innov. Regul. Sci,2019

2. The comprehensive in vitro proarrhythmia assay (CiPA) initiative - update on progress;Colatsky;J. Pharmacol. Toxicol. Methods,2016

3. General principles for the validation of proarrhythmia risk prediction models: an extension of the CiPA in silico strategy;Li;Clin. Pharmacol. Ther,2020

4. Human in silico drug trials demonstrate higher accuracy than animal models in predicting clinical pro-arrhythmic cardiotoxicity;Passini;Front. Physiol,2017

5. Improved prediction of drug-induced torsades de Pointes through simulations of dynamics and machine learning algorithms;Lancaster;Clin. Pharmacol. Ther,2016

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