Calculating qualified non-mutagenic impurity levels: Harmonization of approaches

Author:

Graham Jessica C.ORCID,Powley Mark W.,Udovic ErikaORCID,Glowienke Susanne,Nicolette John,Parris Patricia,Kenyon Michelle,White AngelaORCID,Maisey AilisORCID,Harvey James,Martin Elizabeth A.,Dowdy Eric,Masuda-Herrera Melisa,Trejo-Martin Alejandra,Bercu Joel

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference15 articles.

1. Establishing patient centric specifications for drug substance and drug product impurities;Bercu;J. Pharmaceut. Innov.,2019

2. Regulation (EC) no. 1907/2006 of the European parliament and of the Council of 18 December 2006 concerning the registration, evaluation, authorisation and restriction of chemicals (REACH);CEC;EU CEC Brussels,2006

3. Advancing internal exposure and physiologically-based toxicokinetic modeling for 21st-century risk assessments;Cohen Hubal;J. Expo. Sci. Environ. Epidemiol.,2019

4. Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities. EMA/CHMP/CVMP/SWP/169430/2012;EMA,2014

5. Management of organic impurities in small molecule medicinal products: Deriving safe limits for use in early development;Harvey;Regul. Toxicol. Pharmacol.,2017

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