Assessing the safety of cosmetic chemicals: Consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern)

Author:

Williams Faith M.,Rothe Helga,Barrett Gordon,Chiodini Alessandro,Whyte Jacqueline,Cronin Mark T.D.,Monteiro-Riviere Nancy A.,Plautz James,Roper Clive,Westerhout JoostORCID,Yang Chihae,Guy Richard H.

Funder

European Community's Seventh Framework Program

COSMOS

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference73 articles.

1. Threshold of Toxicological Concern (TTC): a Tool for Assessing Substances of Unknown Toxicity Present at Low Levels in the Diet;Barlow,2005

2. A new method for estimating dermal absorption from chemical exposure. 1. General approach;Cleek;Pharm. Res.,1993

3. Estimation of toxic hazard-a decision tree approach;Cramer;Food Cosmet. Toxicol.,1976

4. Prediction of human drug clearance by multiple metabolic pathways: integration of hepatic and intestinal microsomal and cytosolic data;Cubitt;Drug Metab. Dispos.,2011

5. Skin penetration of epigallocatechin-3-gallate and quercetin from green tea and Ginkgo biloba extracts vehiculated in cosmetic formulations;Dal Belo;Skin Pharmacol. Physiol.,2009

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