How the 62-year old Delaney Clause continues to thwart science: Case study of the flavor substance β-myrcene

Author:

Felter Susan P.,Llewelyn Craig,Navarro Lisa,Zhang Xiaoling

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference74 articles.

1. 21 CFR § 101.22 - Foods; labeling of spices, flavorings, colorings and chemical preservatives. (42 FR 14308, Mar. 15, 1977, as amended at 44 FR 3963, Jan. 19, 1979; 44 FR 37220, June 26, 1979; 54 FR 24891, June 12, 1989; 58 FR 2875, Jan. 6, 1993; 63 FR 14818, Mar. 27, 1998; 74 FR 216, Jan. 5, 2009).

2. 21 CFR § 182.60 - Synthetic flavoring substances and adjuvants. (42 FR 14640, Mar. 15, 1977, as amended at 43 FR 47724, Oct. 17, 1978; 44 FR 3963, Jan. 19, 1979; 44 FR 20656, Apr. 6, 1979; 48 FR 51907, Nov. 15, 1983; 54 FR 7402, Feb. 21, 1989).

3. The FEMA GRAS assessment of aliphatic and aromatic terpene hydrocarbons used as flavor ingredients;Adams;Food Chem. Toxicol.,2011

4. Absence of renal adverse effects from β-myrcene dietary administration in OECD guideline-compliant subchronic toxicity study;Bastaki;Food Chem. Toxicol.,2018

5. Myrcene: a 90-day Dietary Study in Rats. Product Safety Labs. Study No. 33456. May 20, 2013;Bauter,2013

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