Crystal Structure of the Ternary Complex of the Catalytic Domain of Human Phenylalanine Hydroxylase with Tetrahydrobiopterin and 3-(2-Thienyl)-l-alanine, and its Implications for the Mechanism of Catalysis and Substrate Activation

Author:

Andreas Andersen Ole,Flatmark Torgeir,Hough Edward

Publisher

Elsevier BV

Subject

Molecular Biology,Structural Biology

Reference64 articles.

1. The phenylalanine hydroxylating system;Kaufman;Advan. Enzymol. Relat. Areas. Mol. Biol.,1993

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3. PAHdb: A locus-specific knowledgebase;Scriver;Hum. Mutat.,2000

4. Structural insight into the aromatic amino acid hydroxylases and their disease-related mutant forms;Flatmark;Chem. Rev.,1999

5. In vitro expression analysis of mutations in phenylalanine hydroxylase: linking genotype to phenotype and structure to function;Waters;Hum. Mutat.,1998

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