Molecular basis of Celmer’s rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates-Reference-Cited by-同舟云学术

Molecular basis of Celmer’s rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates

Published:2001-04 Issue:4 Volume:8 Page:329-340
ISSN:1074-5521
Container-title:Chemistry & Biology
language:en
Short-container-title:Chemistry & Biology

Author:

Holzbaur Ines E,Ranganathan Anand,Thomas Iain P,Kearney Dominic J.A,Reather James A,Rudd Brian A.M,Staunton James,Leadlay Peter F

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

Reference39 articles.

1. An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea;Cortés;Nature,1990

2. Modular organization of genes required for complex polyketide biosynthesis;Donadio;Science,1991

3. Characterization of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence;Swan;Mol. Gen. Genet.,1994

4. The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin;Schwecke;Proc. Natl. Acad. Sci. USA,1995

5. Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase;Aparicio;Gene,1996

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