Competitive inhibition by inducer as a confounding factor in the use of the ethoxyresorufin-O-deethylase (EROD) assay to estimate exposure to dioxin-like compounds

Author:

Petrulis John R.,Bunce Nigel J.

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference27 articles.

1. Low inducibility of CYP 1A activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): characterization of the Ah receptor and the role of CYP 1A inhibition;Besselink;Fund. Appl. Toxicol.,1998

2. Kinetic and equilibrium studies of Ah receptor-ligand binding: use of [125I]2-iodo-7,8-dibromodibenzo-p-dioxin;Bradfield;Mol. Pharmacol.,1988

3. Additive binding of polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin to the murine hepatic Ah receptor;Brown;Toxicol. Appl. Pharmacol.,1994

4. Kinetic models for association of 2,3,7,8-tetrachlorodibenzo-p-dioxin with the Ah receptor;Bunce;Arch. Biochem. Biophys.,1988

5. Ethoxyresorufin: direct fluorometric assay of a microsomal o-dealkylation which is preferentially inducible by 3-methylcholanthrene;Burke;Drug Metab. Dispos.,1974

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