AC-260584, an orally bioavailable M1 muscarinic receptor allosteric agonist, improves cognitive performance in an animal model

Author:

Bradley Stefania Risso,Lameh Jelveh,Ohrmund Linda,Son Thomas,Bajpai Abhishek,Nguyen Derek,Friberg Mikael,Burstein Ethan S.,Spalding Tracy A.,Ott Thomas R.,Schiffer Hans H.,Tabatabaei Ali,McFarland Krista,Davis Robert E.,Bonhaus Douglas W.

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Pharmacology

Reference40 articles.

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2. M1 muscarinic acetylcholine receptors activate extracellular signal-regulated kinase in CA1 pyramidal neurons in mouse hippocampal slices;Berkeley;Mol. Cell. Neurosci.,2001

3. Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease;Bodick;Arch. Neurol.,1997

4. MAPK, CREB and zif268 are all required for the consolidation of recognition memory;Bozon;Philos. Trans. R. Soc. Lond. B Biol. Sci.,2003

5. Bradley, S.R., McFarland, K., Lameh, J., Friberg, M., Burstein, E.S., Spalding, T.A., Schiffer, H.H., Tolf, B.-R., Bonhaus, D.W., 2008. Pharmacological characterization of AC-260584, a potent and selective M1 muscarinic receptor agonist. ASPET Colloquium: Recent Advances in Muscarinic Receptor Pharmacology and Therapeutics San Diego, CA.

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