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DOR2-selective but not DOR1-selective antagonist abolishes anxiolytic-like effects of the δ opioid receptor agonist KNT-127

  • Published:2014-04 Issue: Volume:79 Page:314-320
  • ISSN:0028-3908
  • Container-title:Neuropharmacology
  • language:en
  • Short-container-title:Neuropharmacology

Author:

Sugiyama Azusa,Nagase Hiroshi,Oka Jun-Ichiro,Yamada Mitsuhiko,Saitoh Akiyoshi

Funder

Intramural Research Grant

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Pharmacology

Reference38 articles.

1. A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers;Bhushan;J. Med. Chem.,2004

2. SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist;Bilsky;J. Pharmacol. Exp. Ther.,1995

3. A functional neuroanatomy of anxiety and fear: implications for the pathophysiology and treatment of anxiety disorders;Charney;Crit. Rev. Neurobiol.,1996

4. The rat formalin test: can it predict neuropathic pain treatments?;Ellis,2008

5. Cloning of a delta opioid receptor by functional expression;Evans;Science,1992
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