Orally bioavailable and brain-penetrant pyridazine and pyridine-derived γ-secretase modulators reduced amyloidogenic Aβ peptides in vivo-Reference-Cited by-同舟云学术

Orally bioavailable and brain-penetrant pyridazine and pyridine-derived γ-secretase modulators reduced amyloidogenic Aβ peptides in vivo

Published:2013-07 Issue: Volume:70 Page:278-286
ISSN:0028-3908
Container-title:Neuropharmacology
language:en
Short-container-title:Neuropharmacology

Author:

Huang Yunhong,Li Ting,Eatherton Andrew,Mitchell William L.,Rong Na,Ye Liang,Yang Xiu-Juan,Jin Shiyi,Ding Yu,Zhang Jinqiang,Li Yi,Wu Yiwen,Jin Yun,Sang Yingxia,Cheng Ziqiang,Browne Edward R.,Harrison David C.,Hussain Ishrut,Wan Zehong,Hall Adrian,Lau Lit-Fui,Matsuoka Yasuji

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Pharmacology

Reference46 articles.

1. Alzheimer's disease facts and figures;Alzheimer's Association;Alzheimer's Demen. J. Alzheimer's Assoc.,2012

2. A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system;Bateman;Ann. Neurol.,2009

3. The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression;Burton;J. Biol. Chem.,2008

4. Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase;Czirr;J. Biol. Chem.,2008

5. Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease;Deane;Curr. Alzheimer Res.,2007

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