Targeting MOR-mGluR5 heteromers reduces bone cancer pain by activating MOR and inhibiting mGluR5-Reference-Cited by-同舟云学术

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Targeting MOR-mGluR5 heteromers reduces bone cancer pain by activating MOR and inhibiting mGluR5

Published:2019-12 Issue: Volume:160 Page:107690
ISSN:0028-3908
Container-title:Neuropharmacology
language:en
Short-container-title:Neuropharmacology

Author:

Shueb Sarah S.,Erb Samuel J.,Lunzer Mary M.,Speltz Rebecca,Harding-Rose Catherine,Akgün Eyup,Simone Donald A.,Portoghese Philip S.

Funder

NIH

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Pharmacology

Reference38 articles.

1. Presynaptic localization of the carboxy-terminus epitopes of the μ opioid receptor splice variants MOR-1C and MOR-1D in the superficial laminae of the rat spinal cord;Abbadie;Neuroscience,2001

2. Perceived dangers from intraspinal steroid injections;Abram;Arch. Neurol.,1989

3. Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception;Akgün;Proc. Natl. Acad. Sci. Unit. States Am.,2013

4. Combined glia inhibition and opioid receptor agonism afford highly potent analgesics without tolerance;Akgün;ACS Chem. Neurosci.,2019

5. Peripheral group I metabotropic glutamate receptors modulate nociception in mice;Bhave;Nat. Neurosci.,2001

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5. Light-Induced Activation of a Specific Type-5 Metabotropic Glutamate Receptor Antagonist in the Ventrobasal Thalamus Causes Analgesia in a Mouse Model of Breakthrough Cancer Pain;International Journal of Molecular Sciences;2022-07-20

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