Simultaneous haploinsufficiency of Pten and Trp53 tumor suppressor genes accelerates tumorigenesis in a mouse model of prostate cancer

Author:

Couto Suzana S.,Cao Mei,Duarte Paulo C.,Banach-Petrosky Whitney,Wang Shunyou,Romanienko Peter,Wu Hong,Cardiff Robert D.,Abate-Shen Cory,Cunha Gerald R.

Publisher

Elsevier BV

Subject

Cancer Research,Cell Biology,Developmental Biology,Molecular Biology

Reference53 articles.

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2. Tumor suppressor genes in prostatic oncogenesis;Bookstein;J. Cell. Biochem.,1994

3. p53 is mutated in a subset of advanced-stage prostate cancers;Bookstein;Cancer Res.,1993

4. Frequent inactivation of PTEN/MMAC1 in primary prostate cancer;Cairns;Cancer Res.,1997

5. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis;Chen;Nature,2005

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