R-2-Hydroxyglutarate as the Key Effector of IDH Mutations Promoting Oncogenesis
Author:
Publisher
Elsevier BV
Subject
Cancer Research,Cell Biology,Oncology
Reference10 articles.
1. The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases
2. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
3. Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
4. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
5. Expanding chemical biology of 2-oxoglutarate oxygenases
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