The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1-Reference-Cited by-同舟云学术

The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1

Published:2020-09 Issue: Volume:202 Page:105724
ISSN:0960-0760
Container-title:The Journal of Steroid Biochemistry and Molecular Biology
language:en
Short-container-title:The Journal of Steroid Biochemistry and Molecular Biology

Author:

Barnard Lise,Nikolaou Nikolaos,Louw Carla,Schiffer Lina,Gibson Hylton,Gilligan Lorna C.,Gangitano Elena,Snoep Jacky,Arlt Wiebke,Tomlinson Jeremy W.,Storbeck Karl-Heinz

Funder

Academy of Medical Sciences

Wellcome Trust

Medical Research Council

Publisher

Elsevier BV

Subject

Cell Biology,Clinical Biochemistry,Endocrinology,Molecular Biology,Molecular Medicine,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference57 articles.

1. A new dawn for androgens: novel lessons from 11-oxygenated C19 steroids;Pretorius;Mol. Cell. Endocrinol.,2017

2. Clinical significance of 11-oxygenated androgens;Turcu;Curr. Opin. Endocrinol. Diabetes Obes.,2017

3. Fall, and resurrection of 11-oxygenated androgens in human physiology and disease;Turcu;Horm. Res. Paediatr.,2018

4. Liquid chromatography – tandem mass spectrometry analysis of human adrenal vein 19-carbon steroids before and after ACTH stimulation;Rege;J. Clin. Endocrinol. Metab.,2013

5. 11β-Hydroxyandrostenedione, the product of cytochrome P450 11β-hydroxylase: a novel substrate for 11β-hydroxysteroid dehydrogenase and 5α-reductase;Swart;J. Steroid Biochem. Mol. Biol.,2013

Cited by 18 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Polystyrene microplastics trigger testosterone decline via GPX1;Science of The Total Environment;2024-10

2. Species variation in steroid hormone-related gene expression contributes to species diversity in sexually dimorphic communication in electric fishes;Hormones and Behavior;2024-08

3. 5α-reduction of epitestosterone is catalysed by human SRD5A1 and SRD5A2 and increases androgen receptor transactivation;The Journal of Steroid Biochemistry and Molecular Biology;2024-07

4. Hypogonadism and nonalcoholic fatty liver disease;Endocrine;2024-05-21

5. Inhibition of the glucocorticoid‐activating enzyme 11β‐hydroxysteroid dehydrogenase type 1 drives concurrent 11‐oxygenated androgen excess;The FASEB Journal;2024-03-29