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Novel 11β-substituted estradiol conjugates: Transition from ERα agonizts to effective PROTAC degraders

  • Published:2022-10 Issue: Volume:223 Page:106154
  • ISSN:0960-0760
  • Container-title:The Journal of Steroid Biochemistry and Molecular Biology
  • language:en
  • Short-container-title:The Journal of Steroid Biochemistry and Molecular Biology

Author:

Luo Guoshun,Li Xinyu,Lin Xin,Lu Xiang,Li Zhenbang,Xiang Hua

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Natural Science Research of Jiangsu Higher Education Institutions of China

Publisher

Elsevier BV

Subject

Cell Biology,Clinical Biochemistry,Endocrinology,Molecular Biology,Molecular Medicine,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference40 articles.

1. Cancer statistics, 2021;Siegel;CA Cancer J. Clin.,2021

2. Key steps for effective breast cancer prevention;Britt;Nat. Rev. Cancer,2020

3. The role of estrogen in the initiation of breast cancer;Russo;J. Steroid Biochem. Mol. Biol.,2006

4. Overcoming endocrine resistance in breast cancer;Hanker;Cancer Cell,2020

5. Breast cancer drug approvals by the US FDA from 1949 to 2018;Leo;Nat. Rev. Drug Discov.,2020

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