A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification

Author:

Goettsch Claudia,Hutcheson Joshua D.,Hagita Sumihiko,Rogers Maximillian A.,Creager Michael D.,Pham Tan,Choi Jung,Mlynarchik Andrew K.,Pieper Brett,Kjolby Mads,Aikawa Masanori,Aikawa Elena

Funder

Kowa Company, Ltd

National Institutes of Health

Danish Diabetes Academy

Novo Nordisk Foundation

Publisher

Elsevier BV

Subject

Cardiology and Cardiovascular Medicine

Reference17 articles.

1. Calcium density of coronary artery plaque and risk of incident cardiovascular events;Criqui;JAMA J. Am. Med. Assoc.,2013

2. Revisiting cardiovascular calcification: a multifaceted disease requiring a multidisciplinary approach;Hutcheson;Semin. Cell Dev. Biol.,2015

3. Dyslipidemia, coronary artery calcium, and incident atherosclerotic cardiovascular disease: implications for statin therapy from the multi-ethnic study of atherosclerosis;Martin;Circulation,2013

4. F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial;Joshi;Lancet,2013

5. A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps;Vengrenyuk;Proc. Natl. Acad. Sci. U. S. A.,2006

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