Manganese disrupts the maturation and degradation of axonal autophagosome leading to hippocampal synaptic toxicity in mice via the activation of LRRK2 on phosphorylation of Rab10-Reference-Cited by-同舟云学术

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Manganese disrupts the maturation and degradation of axonal autophagosome leading to hippocampal synaptic toxicity in mice via the activation of LRRK2 on phosphorylation of Rab10

Published:2024-03 Issue: Volume:915 Page:170021
ISSN:0048-9697
Container-title:Science of The Total Environment
language:en
Short-container-title:Science of The Total Environment

Author:

Ma Zhuo,Liu Kuan,Zhang Rui-feng,Xie Zi-xin,Liu Wei,Xu Bin

Funder

Doctoral Start-up Foundation of Liaoning Province

China Postdoctoral Science Foundation

Postdoctoral Research Foundation of China

China Medical University

Shenyang Municipal Bureau of Science and Technology

Publisher

Elsevier BV

Reference47 articles.

1. Autophagy and the endolysosomal system in presynaptic function;Andres-Alonso;Cell. Mol. Life Sci.,2021

2. A synaptic model of memory: long-term potentiation in the hippocampus;Bliss;Nature,1993

3. Hyperactive LRRK2 kinase impairs the trafficking of axonal autophagosomes;Boecker;Autophagy,2021

4. Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes;Boecker;Curr. Biol.,2021

5. LRRK2 mediates tubulation and vesicle sorting from lysosomes;Bonet-Ponce;Sci. Adv.,2020

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