LRRK2 mediates tubulation and vesicle sorting from lysosomes-Reference-Cited by-同舟云学术

LRRK2 mediates tubulation and vesicle sorting from lysosomes

Published:2020-11-13 Issue:46 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Bonet-Ponce Luis¹^ORCID,Beilina Alexandra¹,Williamson Chad D.²^ORCID,Lindberg Eric³^ORCID,Kluss Jillian H.¹,Saez-Atienzar Sara⁴^ORCID,Landeck Natalie¹^ORCID,Kumaran Ravindran¹,Mamais Adamantios¹,Bleck Christopher K. E.³^ORCID,Li Yan⁵^ORCID,Cookson Mark R.¹^ORCID

Affiliation:

1. Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

2. Cell Biology and Neurobiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

3. Electron Microscopy Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

4. Neuromuscular Diseases Research Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

5. Proteomics Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

The Parkinson disease kinase LRRK2 translocates to the lysosomal membrane triggering lysosomal sorting through JIP4.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference60 articles.

1. Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease

2. LRRK2 Haplotype Analyses in European and North African Families with Parkinson Disease: A Common Founder for the G2019S Mutation Dating from the 13th Century

3. A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci

4. Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

5. Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

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