Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

Author:

Voysey Merryn,Costa Clemens Sue Ann,Madhi Shabir A,Weckx Lily Y,Folegatti Pedro M,Aley Parvinder K,Angus Brian,Baillie Vicky L,Barnabas Shaun L,Bhorat Qasim E,Bibi Sagida,Briner Carmen,Cicconi Paola,Clutterbuck Elizabeth A,Collins Andrea M,Cutland Clare L,Darton Thomas C,Dheda Keertan,Dold Christina,Duncan Christopher J A,Emary Katherine R W,Ewer Katie J,Flaxman Amy,Fairlie Lee,Faust Saul N,Feng Shuo,Ferreira Daniela M,Finn Adam,Galiza Eva,Goodman Anna L,Green Catherine M,Green Christopher A,Greenland Melanie,Hill Catherine,Hill Helen C,Hirsch Ian,Izu Alane,Jenkin Daniel,Joe Carina C D,Kerridge Simon,Koen Anthonet,Kwatra Gaurav,Lazarus Rajeka,Libri Vincenzo,Lillie Patrick J,Marchevsky Natalie G,Marshall Richard P,Mendes Ana V A,Milan Eveline P,Minassian Angela M,McGregor Alastair,Mujadidi Yama F,Nana Anusha,Padayachee Sherman D,Phillips Daniel J,Pittella Ana,Plested Emma,Pollock Katrina M,Ramasamy Maheshi N,Ritchie Adam J,Robinson Hannah,Schwarzbold Alexandre V,Smith Andrew,Song Rinn,Snape Matthew D,Sprinz Eduardo,Sutherland Rebecca K,Thomson Emma C,Török M Estée,Toshner Mark,Turner David P J,Vekemans Johan,Villafana Tonya L,White Thomas,Williams Christopher J,Douglas Alexander D,Hill Adrian V S,Lambe Teresa,Gilbert Sarah C,Pollard Andrew J,Aban Marites,Abeyskera Kushala W.M.,Aboagye Jeremy,Adam Matthew,Adams Kirsty,Adamson James P.,Adewatan Gbadebo,Adlou Syed,Ahmed Khatija,Akhalwaya Yasmeen,Akhalwaya Saajida,Alcock Andrew,Ali Aabidah,Allen Elizabeth R.,Allen Lauren,Alvernaz Felipe B.,Amorim Fabio Santos,Andrade Claudia Sala,Andritsou Foteini,Anslow Rachel,Arbe-Barnes Edward H.,Ariaans Mark P.,Arns Beatriz,Arruda Laiana,Assad Luiza,Azi Paula De Almeida,Azi Lorena De Almeida,Babbage Gavin,Bailey Catherine,Baker Kenneth F.,Baker Megan,Baker Natalie,Baker Philip,Baleanu Ioana,Bandeira Danieli,Bara Anna,Barbosa Marcella A.S.,Barker Debbie,Barlow Gavin D.,Barnes Eleanor,Barr Andrew S.,Barrett Jordan R.,Barrett Jessica,Barrett Kelly,Bates Louise,Batten Alexander,Beadon Kirsten,Beales Emily,Beckley Rebecca,Belij-Rammerstorfer Sandra,Bell Jonathan,Bellamy Duncan,Belton Sue,Berg Adam,Bermejo Laura,Berrie Eleanor,Berry Lisa,Berzenyi Daniella,Beveridge Amy,Bewley Kevin R.,Bharaj Inderjeet,Bhikha Sutika,Bhorat Asad E.,Bhorat Zaheda E.,Bijker Else Margreet,Birch Sarah,Birch Gurpreet,Birchall Kathryn,Bird Adam,Bird Olivia,Bisnauthsing Karen,Bittaye Mustapha,Blackwell Luke,Blacow Rachel,Bletchly Heather,Blundell Caitlin L.,Blundell Susannah R.,Bodalia Pritesh,Bolam Emma,Boland Elena,Bormans Daan,Borthwick Nicola,Bowring Francesca,Boyd Amy,Bradley Penny,Brenner Tanja,Bridges-Webb Alice,Brown Phillip,Brown Claire,Brown-O'Sullivan Charlie,Bruce Scott,Brunt Emily,Budd William,Bulbulia Yusuf A.,Bull Melanie,Burbage Jamie,Burn Aileen,Buttigieg Karen R.,Byard Nicholas,Cabrera Puig Ingrid,Calvert Anna,Camara Susana,Cao Michelangelo,Cappuccini Federica,Cardona Rita,Cardoso João R.,Carr Melanie,Carroll Miles W.,Carson-Stevens Andrew,Carvalho Yasmin de M.,Casey Helen R.,Cashen Paul,Castro Thais R.Y.,Castro Lucia Carratala,Cathie Katrina,Cavey Ana,Cerbino-Neto José,Cezar Luiz Fernando F.,Chadwick Jim,Chanice Chanice,Chapman David,Charlton Sue,Cheliotis Katerina S.,Chelysheva Irina,Chester Oliver,Chiplin Emily,Chita Sunder,Cho Jee-Sun,Cifuentes Liliana,Clark Elizabeth,Clark Matthew,Colin-Jones Rachel,Collins Sarah L.K.,Colton Hayley,Conlon Christopher P.,Connarty Sean,Coombes Naomi,Cooper Cushla,Cooper Rachel,Cornelissen Lynne,Corrah Tumena,Cosgrove Catherine A.,Costa Fernanda Barroso,Cox Tony,Crocker Wendy E.M.,Crosbie Sarah,Cullen Dan,Cunha Debora R.M.F.,Cunningham Christina J.,Cuthbertson Fiona C.,da Costa Daniel Marinho,Da Guarda Suzete N. Farias,da Silva Larissa P.,da Silva Moraes Antonio Carlos,Damratoski Brad E.,Danos Zsofia,Dantas Maria T.D.C.,Datoo Mehreen S.,Datta Chandrabali,Davids Malika,Davies Sarah L.,Davies Kelly,Davies Hannah,Davies Sophie,Davies Judith,Davis Elizabeth J.,Davis John,de Carvalho José A.M.,De Jager Jeanne,de Jesus Jnr Sergio,De Oliveira Kalid Lis Moreno,Dearlove David,Demissie Tesfaye,Desai Amisha,Di Marco Stefania,Di Maso Claudio,Dinesh Tanya,Docksey Claire,Dong Tao,Donnellan Francesca R.,Dos Santos Tannyth Gomes,Dos Santos Thainá G.,Dos Santos Erika Pachecho,Douglas Naomi,Downing Charlotte,Drake Jonathan,Drake-Brockman Rachael,Drury Ruth,Du Plessis Joan,Dunachie Susanna J.,Duncan Andrew,Easom Nicholas J.W.,Edwards Mandy,Edwards Nick J.,Edwards Frances,El Muhanna Omar M.,Elias Sean C.,Ellison-Handley Branwen,Elmore Michael J.,English Marcus Rex,Esmail Alisgair,Essack Yakub Moosa,Farooq Mutjaba,Fedosyuk Sofiya,Felle Sally,Ferguson Susie,Ferreira Da Silva Carla,Field Samantha,Fisher Richard,Fletcher James,Fofie Hazel,Fok Henry,Ford Karen J.,Fothergill Ross,Fowler Jamie,Fraiman Pedro H.A.,Francis Emma,Franco Marilia M.,Frater John,Freire Marilúcia S.M.,Fry Samantha H.,Fudge Sabrina,Furlan Filho Renato,Furze Julie,Fuskova Michelle,Galian-Rubio Pablo,Garlant Harriet,Gavrila Madita,Gibbons Karyna A.,Gilbride Ciaran,Gill Hardeep,Godwin Kerry,Gokani Karishma,Gonçalves Maria Luisa Freire,Gonzalez Isabela G.S.,Goodall Jack,Goodwin Jayne,Goondiwala Amina,Gordon-Quayle Katherine,Gorini Giacomo,Goyanna Alvaro,Grab Janet,Gracie Lara,Green Justin,Greenwood Nicola,Greffrath Johann,Groenewald Marisa M.,Gunawardene Anishka,Gupta Gaurav,Hackett Mark,Hallis Bassam,Hamaluba Mainga,Hamilton Elizabeth,Hamlyn Joseph,Hammersley Daniel,Hanrath Aidan T.,Hanumunthadu Brama,Harris Stephanie A.,Harris Clair,Harrison Thomas D.,Harrison Daisy,Harris-Wright Tara A.,Hart Thomas C.,Hartnell Birgit,Haughney John,Hawkins Sophia,Hayano Laís Y.M.,Head Ian,Heath Paul T.,Henry John Aaron,Hermosin Herrera Macarena,Hettle David B.,Higa Cristhiane,Hill Jennifer,Hodges Gina,Hodgson Susanne,Horne Elizea,Hou Mimi M.,Houlihan Catherine F.,Howe Elizabeth,Howell Nicola,Humphreys Jonathan,Humphries Holly E.,Hurley Katrina,Huson Claire,Hyams Catherine,Hyder-Wright Angela,Ikram Sabina,Ishwarbhai Alka,Iveson Poppy,Iyer Vidyashankara,Jackson Frederic,Jackson Susan,Jaumdally Shameem,Jeffers Helen,Jesudason Natasha,Jones Carina,Jones Christopher,Jones Kathryn,Jones Elizabeth,Jorge Marianna Rocha,Joshi Amar,Júnior Eduardo A.M.S.,Kailath Reshma,Kana Faeeza,Kar Arnab,Karampatsas Konstantinos,Kasanyinga Mwila,Kay Linda,Keen Jade,Kellett Wright Johanna,Kelly Elizabeth J.,Kelly Debbie,Kelly Dearbhla M.,Kelly Sarah,Kerr David,Khan Liaquat,Khozoee Baktash,Khurana Ankush,Kidd Sarah,Killen Annabel,Kinch Jasmin,Kinch Patrick,King Lloyd D.W.,King Thomas B.,Kingham Lucy,Klenerman Paul,Kluczna Diana M.,Knapper Francesca,Knight Julian C.,Knott Daniel,Koleva Stanislava,Lages Pedro M.,Lang Matilda,Lang Gail,Larkworthy Colin W.,Larwood Jessica P.J.,Law Rebecca,Lawrie Alison M.,Lazarus Erica M.,Leach Amanda,Lees Emily A.,Lelliott Alice,Lemm Nana-Marie,Lessa Alvaro Edson Ramos,Leung Stephanie,Li Yuanyuan,Lias Amelia M.,Liatsikos Konstantinos,Linder Aline,Lipworth Samuel,Liu Shuchang,Liu Xinxue,Lloyd Adam,Lloyd Stephanie,Loew Lisa,Lopez Ramon Raquel,Lora Leandro Bonecker,Luz Kleber Giovanni,MacDonald Jonathan C.,MacGregor Gordon,Madhavan Meera,Mainwaring David O.,Makambwa Edson,Makinson Rebecca,Malahleha Mookho,Malamatsho Ross,Mallett Garry,Manning Nicola,Mansatta Kushal,Maoko Takalani,Marinou Spyridoula,Marlow Emma,Marques Gabriela N.,Marriott Paula,Marshall Richard P.,Marshall Julia L.,Masenya Masebole,Masilela Mduduzi,Masters Shauna K.,Mathew Moncy,Matlebjane Hosea,Matshidiso Kedidimetse,Mazur Olga,Mazzella Andrea,McCaughan Hugh,McEwan Joanne,McGlashan Joanna,McInroy Lorna,McRobert Nicky,McSwiggan Steve,Megson Clare,Mehdipour Savviz,Meijs Wilma,Mendonça Renata N.Õ.,Mentzer Alexander J.,Mesquita Ana Carolina F.,Miralhes Patricia,Mirtorabi Neginsadat,Mitton Celia,Mnyakeni Sibusiso,Moghaddas Fiona,Molapo Kgaogelo,Moloi Mapule,Moore Maria,Moran Marni,Morey Ella,Morgans Róisín,Morris Susan J.,Morris Sheila,Morrison Hazel,Morselli Franca,Morshead Gertraud,Morter Richard,Mottay Lynelle,Moultrie Andrew,Moyo Nathifa,Mpelembue Mushiya,Msomi Sibekezelo,Mugodi Yvonne,Mukhopadhyay Ekta,Muller Jilly,Munro Alasdair,Murphy Sarah,Mweu Philomena,Myerscough Christopher,Naik Gurudutt,Naker Kush,Nastouli Eleni,Ndlovu Bongani,Nikolaou Elissavet,Njenga Cecilia,Noal Helena C.,Noé Andrés,Novaes Gabrielle,Nugent Fay L.,Nunes Géssika Lanzillo A.,O'Brien Katie,O'Connor Daniel,Oelofse Suzette,Oguti Blanche,Olchawski Victoria,Oldfield Neil J.,Oliveira Marianne G.,Oliveira Catarina,Oliveira Isabelle Silva Queiroz,Oommen-Jose Aylin,Oosthuizen Angela,O'Reilly Paula,O'Reilly Peter J.,Osborne Piper,Owen David R.J.,Owen Lydia,Owens Daniel,Owino Nelly,Pacurar Mihaela,Paiva Brenda V.B.,Palhares Edna M.F.,Palmer Susan,Parracho Helena M. R.T.,Parsons Karen,Patel Dipak,Patel Bhumika,Patel Faeezah,Patrick-Smith Maia,Payne Ruth O.,Peng Yanchun,Penn Elizabeth J.,Pennington Anna,Peralta Alvarez Marco Polo,Pereira Stuchi Bruno Pereira,Perez Ana Luiza,Perinpanathan Tanaraj,Perring James,Perumal Rubeshan,Petkar Sahir Yusuf,Philip Tricia,Phillips Jennifer,Phohu Mary Kgomotso,Pickup Lorinda,Pieterse Sonja,Pinheiro Jessica Morgana,Piper Jo,Pipini Dimitra,Plank Mary,Plant Sinéad,Pollard Samuel,Pooley Jennifer,Pooran Anil,Poulton Ian,Powers Claire,Presa Fernando B.,Price David A.,Price Vivien,Primeira Marcelo R.,Proud Pamela C.,Provstgaard-Morys Samuel,Pueschel Sophie,Pulido David,Quaid Sheena,Rabara Ria,Radia Kajal,Rajapaska Durga,Rajeswaran Thurkka,Ramos Leonardo,Ramos Alberto San Francisco,Ramos Lopez Fernando,Rampling Tommy,Rand Jade,Ratcliffe Helen,Rawlinson Tom,Rea David,Rees Byron,Resuello-Dauti Mila,Reyes Pabon Emilia,Rhead Sarah,Riaz Tawassal,Ricamara Marivic,Richards Alexander,Richter Alex,Ritchie Neil,Ritchie Adam J.,Robbins Alexander J.,Roberts Hannah,Robinson Ryan E.,Roche Sophie,Rollier Christine,Rose Louisa,Ross Russell Amy L.,Rossouw Lindie,Royal Simon,Rudiansyah Indra,Ryalls Kim,Sabine Charlotte,Saich Stephen,Sale Jessica C.,Salman Ahmed M.,Salvador Natalia,Salvador Stephannie,Sampaio Milla Dias,Samson Annette D.,Sanchez-Gonzalez Amada,Sanders Helen,Sanders Katherine,Santos Erika,Santos Guerra Mayara F.S.,Satti Iman,Saunders Jack E.,Saunders Caroline,Sayed Aakifah Bibi Arif,Schim van der Loeff Ina,Schmid Annina B.,Schofield Ella,Screaton Gavin R.,Seddiqi Samiullah,Segireddy Rameswara R.,Senger Roberta,Serrano Sonia,Shaik Imam,Sharpe Hannah R.,Sharrocks Katherine,Shaw Robert,Shea Adam,Sheehan Emma,Shepherd Amy,Shiham Farah,Silk Sarah E.,Silva-Reyes Laura,Silveira Lidiana B. T.D.,Silveira Mariana B.V.,Singh Nisha,Sinha Jaisi,Skelly Donal T.,Smith Daniel C.,Smith Nick,Smith Holly E.,Smith David J.,Smith Catherine C.,Soares Airanuédida S.,Solórzano Carla,Sorio Guilherme L.,Sorley Kim,Sosa-Rodriguez Tiffany,Souza Cinthia M.C.D.L.,Souza Bruno S.D.F.,Souza Alessandra R.,Souza Lopez Thamyres,Sowole Luciana,Spencer Alexandra J.,Spoors Louise,Stafford Lizzie,Stamford Imogen,Stein Ricardo,Stockdale Lisa,Stockwell Lisa V.,Strickland Louise H.,Stuart Arabella,Sturdy Ann,Sutton Natalina,Szigeti Anna,Tahiri-Alaoui Abdessamad,Tanner Rachel,Taoushanis Carol,Tarr Alexander W.,Tarrant Richard,Taylor Keja,Taylor Ursula,Taylor Iona Jennifer,Taylor Justin,te Water Naude Rebecca,Templeton Kate,Themistocleous Yrene,Themistocleous Andreas,Thomas Merin,Thomas Kelly,Thomas Tonia M.,Thombrayil Asha,Thompson Julia,Thompson Fawziyah,Thompson Ameeka,Thompson Amber,Thompson Kevin,Thornton-Jones Viv,Thotusi Larissa H.S.,Tighe Patrick J.,Tinoco Lygia Accioly,Tiongson Gerlynn Ferreras,Tladinyane Bonolo,Tomasicchio Michele,Tomic Adriana,Tonks Susan,Towner James,Tran Nguyen,Tree Julia A.,Trillana Gerry,Trinham Charlotte,Trivett Rose,Truby Adam,Tsheko Betty Lebogang,Tubb Philippa,Turabi Aadil,Turner Richard,Turner Cheryl,Turner Nicola,Tyagi Bhavya,Ulaszewska Marta,Underwood Benjamin R.,van Eck Samual,Varughese Rachel,Verbart Dennis,Verheul Marije K.,Vichos Iason,Vieira Taiane A.,Walker Gemma,Walker Laura,Wand Matthew E.,Wardell Theresa,Warimwe George M.,Warren Sarah C.,Watkins Bridget,Watson Marion E.E.,Watson Ekaterina,Webb Stewart,Webster Angela,Welch Jessica,Wellbelove Zoe,Wells Jeanette H.,West Alison J.,White Beth,White Caroline,White Rachel,Williams Paul,Williams Rachel L.,Willingham Silvia,Winslow Rebecca,Woods Danielle,Woodyer Mark,Worth Andrew T.,Wright Danny,Wroblewska Marzena,Yao Andy,Yim Yee Ting Nicole,Zambrano Marina Bauer,Zimmer Rafael Leal,Zizi Dalila,Zuidewind Peter

Funder

Bill and Melinda Gates Foundation

NIHR

UKRI

CEPI

Publisher

Elsevier BV

Subject

General Medicine

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