Toxic effects of Tripterygium glycoside tablets on the reproductive system of male rats by metabolomics, cytotoxicity, and molecular docking

Author:

Ge Jia-Chen,Qian Qi,Gao Yan-Hua,Zhang Yi-Fan,Li Ying-Xuan,Wang Xu,Fu Yan,Ma Yu-Mei,Wang Qiao

Funder

National Natural Science Foundation of China

Hebei Province Department of Education

Natural Science Foundation of Hebei Province

Hebei Province Department of Science And Technology

Hebei Medical University

Administration of Traditional Chinese Medicine of Jilin Province

Publisher

Elsevier BV

Subject

Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine

Reference51 articles.

1. Effects of demethylzeylasteral and celastrol on spermatogenic cell Ca2+ channels and progesterone-induced sperm acrosome reaction;Bai;Eur. J. Pharmacol.,2003

2. Application and prospect of metabolomics in traditional Chinese medicine research;Cui;Chin. Tradit. Herb. Drugs,2022

3. Effect of Tripterygium Glycosides Tablets on reproductive toxicity in male rats with II type collagen induced arthritis;Fan;China J. Chin. Mater. Medica,2020

4. Effect of Tripterygium Glycosides Tablets on reproductive toxicity in female rats with II type collagen induced arthritis;Fan;China J. Chin. Mater. Medica,2019

5. Enhancement of motility and acrosome reaction in human spermatozoa: differential activation by type-specific phosphodiesterase inhibitors;Fisch;Hum. Reprod. Oxf. Engl.,1998

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