Shikonin, a naphthalene ingredient: Therapeutic actions, pharmacokinetics, toxicology, clinical trials and pharmaceutical researches

Author:

Sun Qiang,Gong Ting,Liu Maolun,Ren Shan,Yang Han,Zeng Sha,Zhao Hui,Chen Li,Ming Tianqi,Meng Xianli,Xu Haibo

Publisher

Elsevier BV

Subject

Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine

Reference238 articles.

1. N-end rule pathway inhibition assists colon tumor regression via necroptosis;Agarwalla;Mol. Ther. Oncolytics,2016

2. Addition of beta-lactoglobulin produces water-soluble shikonin;Albreht;J. Agric. Food Chem.,2012

3. Shikonin prevents early phase inflammation associated with azoxymethane/dextran sulfate sodium-induced colon cancer and induces apoptosis in human colon cancer cells;Andujar;Planta Med.,2018

4. Improved isolation procedure for shikonin from the root of the Chinese medicinal plant Lithospermum erythrorhizon and its solubilization with cyclodextrins;Azuma;J. Appl. Res. Med. Aroma,2016

5. Shikonin inhibits migration and invasion of triple-negative breast cancer cells by suppressing epithelial-mesenchymal transition via miR-17-5p/PTEN/Akt pathway;Bao;J. Cancer,2021

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